Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)
Dept of Defense · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
This notice is not accepting responses (deadline was Jun 23, 2026, 8:00 PM EDT).
Page kept for research and related open opportunities below. For current work in this category, use the related notices or browse hubs.
- Response deadline
- Jun 23, 2026, 8:00 PM EDT
- Posted
- May 17, 2026
- Solicitation
- DARPA-SN-26-67
- Set-aside
- None listed
- Place of performance
- —
- Contracting office
- DEF ADVANCED RESEARCH PROJECTS AGCY · ARLINGTON · VA
- Source
- SAM.gov · updated May 19, 2026
Description
UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.
What similar awards have paid
Real federal awards already on the books in a similar lane — so you can size the opportunity, not guess. This is public history, not a bid price, cost estimate, or prediction that you will win.
Typical award size
$517,831
Middle of the pack for similar past awards
Most similar awards fall between $50,502 and $3.57M
Who has won work like this
Public awardees in this lane — useful for competitor scan or teaming ideas, not a ranked list of “best” firms.
- 1AMGEN USA INC1 award$713.89M
- 2ADVANCED TECHNOLOGY INTERNATIONAL3 awards$531.67M
- 3MAPP BIOPHARMACEUTICAL, INC.2 awards$295.66M
- 4EMERGENT BIODEFENSE OPERATIONS LANSING LLC1 award$211.41M
- 5ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)1 award$158.81M
- 6PPD DEVELOPMENT LP2 awards$152.02M
- 7START2 GROUP, INC.1 award$138.08M
- 8BASILEA PHARMACEUTICA INTERNATIONAL LTD, ALLSCHWIL2 awards$118.95M
Recent examples
A few of the newest similar awards in our index.
- AURO VACCINES LLCSep 30, 2025Department of Health and Human Services$10.73MSource
- START2 GROUP, INC.Sep 30, 2025Department of Health and Human Services$138.08MSource
- UNIVERSITY LAB PARTNERSSep 30, 2025Department of Health and Human Services$21.12MSource
- CIDARA THERAPEUTICS INCSep 30, 2025Department of Health and Human Services$58.05MSource
- CRYPTOBIOTIXSep 30, 2025Department of Agriculture$47,000Source
- THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTERSep 30, 2025Department of Health and Human Services$1.18MSource
Drawn from official USAspending contract records in our index. Always confirm requirements on the SAM.gov notice before you bid.
Intelligence only — not legal advice or a guarantee of award. Always verify requirements on the official SAM.gov notice. Past award amounts are public history, not a suggested bid or prediction. Notice ID 553632b7e7fd49a7884a1c32f8a611c5.