Smart Red Blood Cells (Smart-RBC)
Dept of Defense · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
This notice is not accepting responses (deadline was Jan 14, 2026, 11:59 PM EST).
Page kept for research and related open opportunities below. For current work in this category, use the related notices or browse hubs.
- Response deadline
- Jan 14, 2026, 11:59 PM EST
- Posted
- Oct 17, 2025
- Solicitation
- DARPA-PS-26-02
- Set-aside
- None listed
- Place of performance
- —
- Contracting office
- DEF ADVANCED RESEARCH PROJECTS AGCY · ARLINGTON · VA
- Source
- SAM.gov · updated Jul 5, 2026
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in support of the Smart Red Blood Cells program (Smart-RBC). The DARPA Smart-RBC program aims to engineer red blood cells to contain novel biological features that can safely, temporarily, and reliably alter human physiology. Specifically, the Smart-RBC program will revolutionize blood products by creating �smart red blood cells� (SRBCs). SRBCs will be engineered to contain additional biological circuits consisting of three layers: Sense extracellular biomarkers; Decide next steps; Act by creating effector molecules that can alter metabolism or physiology. The program will identify the art-of-the-possible to create SRBCs to enhance human performance and maximize survival via hemostasis products. This program does not include clinical trials or direct human testing.
What similar awards have paid
Real federal awards already on the books in a similar lane — so you can size the opportunity, not guess. This is public history, not a bid price, cost estimate, or prediction that you will win.
Typical award size
$404,976
Middle of the pack for similar past awards
Most similar awards fall between $45,429 and $2.81M
Who has won work like this
Public awardees in this lane — useful for competitor scan or teaming ideas, not a ranked list of “best” firms.
- 1ADVANCED TECHNOLOGY INTERNATIONAL5 awards$2.27B
- 2AMGEN USA INC2 awards$714.70M
- 3SIGA TECHNOLOGIES, INC.1 award$624.44M
- 4ICON GOVERNMENT AND PUBLIC HEALTH SOLUTIONS, INC.5 awards$383.82M
- 5ALLUCENT GOVERNMENT SERVICES (US) LLC5 awards$375.68M
- 6TECHNICAL RESOURCES INTERNATIONAL, INC.9 awards$363.64M
- 7MAPP BIOPHARMACEUTICAL, INC.4 awards$315.08M
- 8ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)2 awards$305.87M
Drawn from official USAspending contract records in our index. Always confirm requirements on the SAM.gov notice before you bid.
Intelligence only — not legal advice or a guarantee of award. Always verify requirements on the official SAM.gov notice. Past award amounts are public history, not a suggested bid or prediction. Notice ID a0160217c997497c897c3320db9dcb7f.