Q517--Bayesian-Guided medication dosing software 660-27-1-062-0002

Description

Sources Sought Notice Sources Sought Notice Sources Sought Notice *= Required Field Sources Sought Notice Sources Sought Notice Bayesian Dosing Software (Single Site Standalone License) Disclaimer: This Request for Information (RFI) is issued solely for market research information and planning purposes and does not constitute a solicitation. All information received in response to this RFI that is marked as proprietary will be handled accordingly. Responses to this notice are NOT offers and cannot be accepted by the Government to form a binding contract. Responders are solely responsible for all expenses associated with responding to this RFI. Information Requested from Industry: In response to the Sources Sought, interested Contractors shall submit the following information and any Capabilities/Qualifications Statement to include but not limited to an overview of proposed solution(s) and a description of the product your company possesses in accordance with the Statement of Work draft / Salient Characteristics List. Responses to market research table questionnaire shall be submitted. If this information is not provided, then it will be assumed the entire requirement cannot be met. Description of Requirement: The Department of Veterans Affairs, Veterans Health Administration (VHA), Network Contracting Office 19 (NCO 19) is conducting a market survey and is seeking potential sources for a Bayesian Dosing Software, including single site standalone licensing. This Sources Sought Notice is issued for information and planning purposes only. This is not a solicitation or a request for proposal and shall not be construed as an obligation or commitment by the Government. An award will not be made on any offers submitted in response to this notice, and it shall not be implied that the Government is committed to providing any solicitation or award following this notice. The Government will not pay for any information received in response to this request, nor will the Government compensate a respondent for any costs incurred in developing the information provided. Requirement Item: Bayesian Dosing Software Single Site - Standalone Licensing STATEMENT OF WORK Introduction and Overview This statement of work is for a subscription to a Bayesian-guided medication dosing software from a contractor that can provide licensing rights. This subscription is to ensure clinicians have access to a reliable web-based therapeutic drug dosing and monitoring tool for complex clinical situations that require careful drug therapy evaluation and adjustment in a systematic and efficient manner. The software will include important pharmacokinetic parameters and empiric and patient-specific dosing recommendations; allow for graphical prediction and projection of theoretical doses at any drug dosing interval in order to optimize and achieve therapeutic drug levels; provide local storage of data and references for primary literature of clinicals models used; and lastly, be highly customizable, HIPAA and GDPR compliant, and meet VA information security requirements by only providing patient de-identification information on the web-based platform. Must be fully compliant with the IDSA/ASHP Vancomycin 2020 guidelines. Background Intravenous vancomycin remains an important first-line antibiotic used for treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Recent Consensus Guidelines (Rybak MJ et al, AM J HEALTH-SYST PHARM, March 2020) for vancomycin therapeutic monitoring now recommend vancomycin dose optimization preferably using a Bayesian-guided software to achieve individualized targeted concentrations that maximize clinical efficacy while minimizing renal toxicity. Veterans Affairs Healthcare Systems are complex in scope of services; thus, clinical providers require access to a validated, systematic, and intuitive clinical tool to dose and monitor drug therapy safely. Scope of Work The contractor shall provide all resources necessary and have an established Business Associate Agreement with the Department of Veterans Affairs to meet requirements and accomplish the deliverables described in this statement of work (SOW), except as may otherwise be specified. The contractor shall provide uninterrupted licensing and subscription services to a Bayesian-guided medication dosing software as stated herein for clinical staff within the VA Salt Lake City Health Care System. Performance Period Contract will start� December 12/1/2026 to 11/30/2027 with� four� 12-month� renewal� options. Periods of Performance 12/1/2026 to 11/30/2027 Base Year 12/1/2027 to 11/30/2028 Option year 1 12/1/2028 to 11/30/2029 Option year 2 12/1/2029 to 11/30/2030 Option year 3 12/1/2030 to 11/30/2031 Option year 4 Requirements License rights to� a� web-based pharmacokinetics medication dosing software� program� from a contractor that can provide license rights equivalent to or exceeding the product listing offered by the� proprietor.� Web-based program that can be found from any web browser with an internet connection. Capability to integrate into VISTA and CERNER electronic health record (EHR) so the tool can automatically retrieve all required data available in the hospital s health records and use to provide estimated dosing recommendations. Provide input data storage capability with database searchable by patient name, patient identification, drug name, or date. Unlimited� and� simultaneous user� access� must be available online� 24� hours a day� 7� days a week� via web� from any government owned equipment (authenticated by IP address)� as well as� remote access� for� virtual employees. Provide capable de-identify patient data base for VA population� Software to include additional� drug� specific� factors� that may influence the patient s pharmacokinetic� profile or dosing regimen such as amputation, obesity, pregnancy,� critically ill, burn patient, hematology/oncology patient, spinal cord injury, cystic fibrosis,� significant drug-drug interactions,� and� drug-disease state interactions.� � Software to include the option to incorporate� patient specific data� points age, gender, weight, height, renal function,� dosage history,� drug� serum concentrations,� dialysis history, and� previous vancomycin history.� � Software to display population pharmacokinetic parameters details such as clearance, volume of distribution, half-life, etc.� Drug monitoring to include serum level graphs with options to display population� data, individual/patient specific data, therapeutic� range,� toxicity� and serum levels.� � Include ability to specify therapeutic targets (AUC, trough, peak) and receive recommended dose and interval based on selected target.� � Ability to propose recommended dosing regimens with and without patient serum drug levels, with ability to incorporate non-steady state and irregular situations. Program to provide warning to user if there is detection of a potentially toxic dose, serum level, or if outside recommended AUC range.� � Program� to have option for inter-site sharing of patient case data� including drug dosing and monitoring information� Access to all drug kinetics offered within the program and any new drug kinetics added in the future. Software to include Veteran population kinetic model using data based on the VA's specific population; model should be updated quarterly at a minimum; includes Vancomycin, Aminoglycosides, Antibiotics, Anticonvulsants, Antiarrhythmic, Antifungal, Oncology, Transplants medications. Reports and data analytics to be made available to users quarterly for users to access, download and/or print. Ability to generate patient specific and population reports that are customizable by the user. Tasks and Associated Deliverables The contractor shall provide a detailed proposal responsive to this SOW. All written deliverables shall be phrased in layperson language. Statistical and other technical terminology shall not be used without providing a glossary of terms. The contractor shall provide uninterrupted licensing and subscription services to an electronic medical reference as stated herein. The contractor shall provide product training, online tutorials, and promotional material. Contractor shall also provide unlimited support via virtual training performed by a person with a clinical background during implementation. Contractor shall provide technical support numbers. Customer service shall be available to provide unlimited technical support 24 hours a day, 7 days a week to troubleshoot website/connectivity issues. The contractor is expected to troubleshoot access as needed. The contractor shall have the ability to provide usage statistics on a quarterly basis. The format of the usage statistics is provided either via email or contractor provided login. Contractor to provide support documentation tools, such as clinical or technical manual. Evaluation Contractors shall allow a pre-identified panel of subject matter experts access to the Bayesian-guided medication dosing software to for evaluation purposes. Evaluation factors will be based on requirements and deliverables in this SOW, with focus of factors in section 5 Requirements of this SOW. A standardized list of evaluation factors will be used to evaluate requirements listed in this SOW. Changes to Statement of Work Any changes to this SOW shall be authorized and approved only through written correspondence from the CO. A copy of each change will be kept in a project folder along with all other products of the project. Costs incurred by the contractor through the actions of parties other than the CO shall be borne by the contractor. Travel The contractor is responsible for any travel expenses related to on-site training or other customer service tasks associated with deliverables. 10. Invoicing and Payment The contractor shall submit in arrears a properly completed itemized invoice in accordance with RFO clauses 52.212-4(g) Terms and Conditions Commercial Products and Commercial Services, via Tungsten Network, http://www.tungsten-network.com/US/. Invoices submitted for payment shall be reviewed for accuracy and shall be subject to approval by the Government prior to issuance of payment. The invoice MUST be itemized to include the following information: 1. Facility name and address where service was provided 2. Contract number 3. Purchase order number 4. Hours 5. Cost 6. Date No advance payments shall be authorized. Payment shall be made on a monthly arrears for services provided during the billing month in arrears in accordance with RFO 52.212-4, para. (i) Upon submission of a properly prepared invoice for prices stipulated in this contract for services delivered and accepted in accordance with the terms and conditions of the contract, less any deductions stipulated in this contract. Payment of invoices may be delayed if the appropriate invoices as specified in the contract is not completed and submitted as required. In response to this announcement, please provide the information requested below requested in this market research table questionnaire. If this information is not provided, then it will be assumed the entire requirement cannot be met: NAICS Code: Company Name: Address: UEI (Unique Entity ID) Number: Contact Name: Phone No.: Email: Business Size Information - Select all that applies: Small Business Emerging Small Business Small Disadvantaged Business Certified under Section 8(a) of the Small Business Act HUBZone Woman Owned Certified Service-Disabled Veteran Owned Small Veteran Owned Small Business Large Business FSS/GSA Contract Holder: Yes No FSS/GSA Contract Number: Effective Date/ Expiration Date: Proposed solution is listed and available on the above FSS/GSA Contract: Yes No Available pricing structure of proposed solution Pricing Model Please Indicate Availability Below: (Yes / No / NA) All on FSS Open Market only Mix of FSS & Open Market Firm-Fixed Price Other: (Please explain) Market Rearch Questions: How long from receipt of order to delivery? Buy American Act RFO 52.225-1 and RFO 52.225-2 Buy American Certificate What percentage of the proposed product (including leases and rentals) is a: Domestic end product? _____________ (%) Foreign end product? _______________ (%) Country of Origin: Questions for Small Businesses ONLY: Per RFO 52.219-14 the following conditions must be met: Supplies (other than procurement from a nonmanufacturer of such supplies), it will not pay more than 50 percent of the amount paid by the Government for contract performance, excluding the cost of materials, to subcontractors that are not similarly situated entities. Any work that a similarly situated entity further subcontracts will count towards the prime contractor's 50 percent subcontract amount that cannot be exceeded. When a contract includes both supplies and services, the 50 percent limitation shall apply only to the supply portion of the contract. If subcontracting, what added value do you offer (RFO 52.215-23): Nonmanufacturer Rule (RFO 52.219-33): Does your company manufacturer these proposed items? [� ] yes [� ] no Does your company exceed 500 employees? [� ] yes [� ] no If yes, list # of employees: _________ Does your company primarily engaged in the retail or wholesale trade and normally sells the type of item being supplied? [� ] yes [� ] no Does your company take ownership or possession of the item(s) with its personnel, equipment or facilities in a manner consistent with industry practice? [� ] yes [� ] no Does your company supply the end item of a small business manufacturer, processor or producer made in the United States, or obtains a waiver of such requirement pursuant to paragraph (b)(5) CFR 121.406. [� ] yes [� ] no If yes, what is the manufacturer s name? ________________ Response Instructions: Do not provide more than 8 pages, including cover letter page. Submit your response via email to eric.ayers@va.gov. Submit your response NLT 2:00 PM (MST) on Tuesday, July 21, 2026. Mark your response as Proprietary Information if the information is considered business sensitive. VA has identified the appropriate North American Industry Classification System (NAICS) Code as 339114 Dental Equipment and Supplies Manufacturing with a Small Business size of 750 Employees. Please identify and explain any NAICS codes your company believes would better represent the predominant work included in the attached Statement of Work draft / Salient Characteristics List.