ClosedPresolicitation
Health and Human Services, Department of contract category

Renewal of licensing fee for the transgenic mouse strain, B-hIL2RA

Health and Human Services, Department of · NATIONAL INSTITUTES OF HEALTH

This notice is not accepting responses (deadline was Jun 7, 2026, 8:00 PM EDT).

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Response deadline
Jun 7, 2026, 8:00 PM EDT
Posted
May 27, 2026
Solicitation
75N98026Q00467
Set-aside
No Set aside used
Place of performance
MD, USA
Contracting office
NATIONAL INSTITUTES OF HEALTH OLAO · BETHESDA · MD
Source
SAM.gov · updated Jun 1, 2026

Description

The MIB is conducting pre-clinical research on photoimmunotherapy (PIT), a targeted treatment approach that uses light activation to destroy specific cells. One area of this research focuses on IL2RA, a protein expressed on regulatory T cells (Tregs). These cells can reduce the immune system�s ability to respond effectively to cancer. The objective of this work is to selectively eliminate IL2RA-expressing Tregs in order to improve anti-cancer immune responses. To support this research, MIB uses a transgenic mouse strain known as B-hIL2RA, which expresses the human form of IL2RA rather than the mouse form. Use of this model is essential because it enables evaluation of the same treatment materials, including antibodies, that are intended for future human application. As a result, this mouse strain has proven invaluable in the MIB�s ongoing research program. The MIB is requesting to renew a licensing fee for transgenic mice, B-hIL2RA. B-hIL2RA transgenic mice.

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